D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase (, D-beta-D-heptose 7-phosphate kinase/D-beta-D-heptose 1-phosphate adenylyltransferase, D-glycero-D-manno-heptose-1beta-phosphate adenylyltransferase, hldE (gene), rfaE (gene)) is an enzyme with systematic name ATP:D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase. It catalyses the following chemical reaction
The enzyme characterised from Escherichia coli transfers an adenylyl group from adenosine triphosphate (ATP) to a specific heptose sugar, D-glycero-β-D-manno-heptose 1-phosphate, giving the adenosine diphosphate derivative, ADP-D-glycero-β-D-manno-heptose.
The product is subsequently converted to ADP-L-glycero-β-D-manno-heptose by the enzyme ADP-glyceromanno-heptose 6-epimerase. This material is used by bacteria to make glycoproteins and polysaccharides.
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