DeLeon or De Leon is a surname. Notable people with the surname include:
Alexander DeLeon (born 1989), US musician Count de Leon (1788–1834), German alchemist and mystic, born Bernhard Müller Carlos De León (1959–2020), Puerto Rico-born US athlete in boxing Daniel De Leon (1856–1914), US political activist and newspaper editor Daryl DeLeon (born 2005), Filipino-British racing driver Edwin de Leon (1818–1891), US lawyer and newspaper editor Gloria DeLeon (born 1952), US social worker Idalis DeLeón (born 1966), US singer and television personality Jack DeLeon (1924–2006), US television actor José DeLeón (born 1960), Dominican Republic-born US athlete in baseball Kevin de León (born 1966), US politician Leroy DeLeon (1948–2025), Trinidad and Tobago footballer Luis DeLeón (born 1958), Puerto Rico-born US athlete in baseball Millie DeLeon (1873–1922), US stage performer Nick DeLeon (born 1990), US football player Oscar D'León (born 1943), Venezuelan musician Rafael de Leon (1908–1999), Trinidad & Tobago musician, known as Roaring Lion Ronnie Deleon (), US kickboxer Russ DeLeon (born 1965), US attorney and co-founder of PartyGaming Skylar Deleon (born 1979), US actor convicted of a 2004 murder Walter DeLeon (1884–1947), US screenwriter