Castello or Castelló is a surname. Notable people with the surname include:
Abraham Isaac Castello (1726–1789), Italian rabbi, preacher and poet, father of Joseph Castello Bernardo Castello (1557–1629), Italian Mannerist painter Castellino Castello (1580–1649), Italian Baroque painter Dan Castello (1836–1909), American showman, animal trainer, clown and circus director Dario Castello (1602–c. 1631), Italian composer and violinist Eduardo Castelló (1940–2020), Spanish racing cyclist Fabrizio Castello (1562–1617), Italian painter of Genoese origin in Spain, son of Givanni Battista Castello Félix Castello (1595–1651), Spanish Baroque painter Florencio Castelló (1905–1986), Spanish actor in Mexican films Francesc de Paula Castelló Aleu (1914–1936), Spanish Roman Catholic beatified martyr Giovanni Battista Castello (c. 1500–c. 1579), Italian painter Ignazio Paternò Castello, Prince of Biscari (1722–1786), Italian polymath, antiquarian, patron of the arts and Sicilian noble John Castello (1802–1877), Guyanese child actor and newspaper publisher and editor Joseph Castello (c. 1746–?), Italian Jewish physician Julia Castelló (born 1990), Spanish Paralympic swimmer Marco Castello (born 1993), Italian singer-songwriter, composer, record producer and multi-instrumentalist Marie Castello (1915–2008), American fortune teller and psychic reader Núria Castelló (born 1971), Spanish backstroke swimmer Pere Martí Castelló (born 1982), Spanish former footballer Sandra Castelló (born 1993), Spanish footballer Sebastian Castello (soccer) (born 2003), Canadian soccer player Sebastian Castellio (1515–1563), also spelled Castello, French theologian Valerio Castello (1624–1659), Italian Baroque painter Vicente Castelló (c. 1585–1636), Spanish Baroque painter Willy Castello (1910–1953), Dutch-American film actor
See also Adriano Castellesi (c. 1461-c. 1521), also known as Adriano de Castello or Hadrian de Castello, Italian cardinal, English agent in Rome and writer Alberto Bottari de Castello (1942–2025), Italian prelate of the Catholic Church Henry, Count of Malta, Enrico da Castello (died c. 1230), Italian fleet captain and corsair Guido di Costello, birth name of Pope Celestine II (died 1144) Margaret of Castello (1287–1320), Italian Catholic educator and Dominican tertiary nun Salvador Espriu i Castelló (1913–1985), Catalan poet Santos Abril y Castelló (born 1935), Spanish prelate of the Catholic Church