Casale is an Italian surname. Notable people with the surname include:
Gerald Casale (born 1948), American musician Giovanni Casale (born 1980), Italian judoka Giuseppe Casale (1923–2023), Italian bishop Ignacio Casale (born 1987), Chilean four-wheeler motorcycle rider Jean Casale (1893–1923), French World War I flying ace credited with thirteen aerial victories Jerry Casale (1933–2019), American Major League Baseball pitcher Luigi Casale (1882–1927), industrial chemist Marcela Casale (born 1986), Italian female field hockey player for the Italian national team Mark Casale (born 1962), former American football player Nathalie Alonso Casale (born 1970), Dutch filmmaker Nicolò Casale (born 1998), Italian football player Pamela Casale-Telford (née Casale; born 1963), American former professional tennis player Primo Casale (1904–1981), Italian-born Venezuelan conductor, composer, and violinist Rita Casale (born 1968), Italian-German educationalist, philosopher and university lecturer Roger Casale (born 1960), former Labour Member of Parliament for Wimbledon Rossana Casale (born 1959), Italian singer Stefano Casale (born 1971), Italian footballer Suzanne Casale Melone (born 1979), birthname of the American freestyle/pop singer Li Suzy; Ubertino da Casale (1259–1329), Italian theologian