Cairo is a surname. Notable people with the surname include:
Ellery Cairo (born 1978), Dutch soccer player Ferdinando del Cairo (1666–1748), Italian Baroque painter Francesco Cairo (1607–1665), Italian painter Hannah Cairo (born 2008), American mathematician Miguel Cairo (born 1974), Major League Baseball player Sofía Cairo (born 2002), Argentine field hockey player Tommy Cairo (born 1958), American professional wrestler Urbano Cairo (born 1957), Italian businessman and chairman of the Torino football club