Putrescine aminotransferase (, putrescine-alpha-ketoglutarate transaminase, YgjG, putrescine:alpha-ketoglutarate aminotransferase, PAT, putrescine:2-oxoglutarate aminotransferase, putrescine transaminase) is an enzyme with systematic name butane-1,4-diamine:2-oxoglutarate aminotransferase. This pyridoxal phosphate-dependent enzyme catalyses the following chemical reaction
The two substrates of this enzyme first characterised Escherichia coli are putrescine and α-ketoglutaric acid. Its initial products are 4-aminobutanal and L-glutamic acid. In this bacterium, the reaction is part of the breakdown pathway of the amino acid arginine.
4-aminobutanal is unstable under these reaction conditions as its aldehyde functional group can cyclise readily with the amino group, losing water:
4-aminobutanal or 1-pyrroline are the starting substrates for the next enzyme in the pathway, aminobutyraldehyde dehydrogenase.
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