Frame is a surname. Notable people with the surname include:
Billy Frame (1912–1992), Scottish footballer Bobby Frame (1959–2025), American politician in Oklahoma Elizabeth Frame, Canadian writer and historian Esther G. Frame (1840–1920), American Quaker minister and evangelist Fred Frame (1894–1962), American race car driver Janet Frame (1924–2004), New Zealand writer John Frame (disambiguation), several people Linley Frame (born 1971), Australian swimmer Margaret Frame (1903–1985), Canadian painter Margaret Frame, British biologist Pete Frame (born 1942), English music journalist Peter Frame (1957–2018), American ballet dancer Roddy Frame (born 1964), Scottish singer-songwriter and musician (Aztec Camera) Tom Frame (1931–2006), British comic letterer Tom Frame (born 1962), Australian Anglican Bishop William Frame (1848–1906), English architect William Frame (cricketer) (1932–1965), New Zealand cricketer and murder-suicide perpetrator Willie Frame (fl. 1920s), Scottish footballer for Clyde, Motherwell and Linfield Willie Frame (curler), Scottish curler, European champion
Fictional characters Alice Frame and Steve Frame, on the soap opera Another World