O-phospho-L-seryl-tRNA:Cys-tRNA synthase (, SepCysS, Sep-tRNA:Cys-tRNA synthase) is an enzyme with systematic name O-phospho-L-seryl-tRNACys:hydrogen sulfide 2-aminopropanoate transferase. This enzyme catalyses the following chemical reaction

O-phospho-L-seryl-tRNACys + sulfide L-cysteinyl-tRNACys + phosphate

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