Seltzer is a surname. Notable people with the surname include:
Aaron Seltzer (born 1974), with Jason Friedberg, screenwriter and director of parody films David Seltzer (born 1940), American screenwriter, producer, and director H. Jack Seltzer (1922–2011), American politician Jerry Seltzer (born 1932), second and final owner of the original Roller Derby league Leo Seltzer (1903–1978), who co-created the sport of roller derby Margaret Seltzer (born 1975), American writer Nachman Seltzer (born 1978), Orthodox Jewish writer Olaf C. Seltzer (1877–1957), Danish-born American painter Stan Seltzer, piano player in the Stan Seltzer Trio Thomas Seltzer, translator and editor of Russian stories Happy-Tom, born Thomas Seltzer, bassist and main songwriter in the band Turbonegro Walter Seltzer (born 1914), film producer Wendy Seltzer, American lawyer