S-methyl-5'-thioinosine phosphorylase (, MTIP, MTI phosphorylase, methylthioinosine phosphorylase) is an enzyme with systematic name S-methyl-5'-thioinosine:phosphate S-methyl-5-thio-alpha-D-ribosyl-transferase. This enzyme catalyses the phosphorolysis reaction in which orthophosphate (Pi) cleaves a ribose sugar:
This is the second step in the catabolism of 5′-methylthioadenosine in Pseudomonas aeruginosa. The first step is a deamination catalysed by S-methyl-5'-thioadenosine deaminase to give S-methyl-5'-thioinosine, which is the substrate here. The products are S-methyl-5-thio-α-D-ribose 1-phosphate and hypoxanthine.
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