Glucosyl-3-phosphoglycerate synthase (, GpgS protein, GPG synthase, glucosylphosphoglycerate synthase) is an enzyme with systematic name NDP-glucose:3-phospho-D-glycerate 2-alpha-D-glucosyltransferase. It catalyses the following chemical reaction
This transfers a glucose unit to 3-phospho-D-glyceric acid to give its glucosyl derivative. The enzyme characterised from Persephonella marina can use GDP-glucose or ADP-glucose in the reaction. However, the enzyme in Methanococcoides burtonii can only use GDP-glucose. The enzyme is also present in Mycobacterium tuberculosis. In these organisms, a second reaction catalysed by glucosyl-3-phosphoglycerate phosphatase forms 2-O-(α-D-glucopyranosyl)-D-glyceric acid by removal of the phosphate group.
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