Challis is a surname. Notable people with the surname include:
Alva Challis (1930–2010), Welsh-born New Zealand geologist Christopher Challis (1919–2012), British cinematographer Ellie Challis (born 2004), British Paralympic swimmer George Challis (rugby league) (1889–1965), Australian rugby player Gordon Challis (1932–2018), New Zealand poet James Challis (1803–1882), British clergyman and astronomer John Challis (1942–2021), English actor John Henry Challis, Anglo-Australian merchant and philanthropist Louis Challis (1936–2017), Australian acoustical engineer Vivien Challis, Australian mathematician
See also Chalis, surname