Aspe is a surname. Notable people with the surname include:
Alberto García Aspe (born 1967), Mexican footballer Elisabeth Aspe (1860–1927), Estonian writer Mauricio Aspe (born 1973), Mexican actor Pedro Aspe (born 1950), Mexican economist Pieter Aspe (1953–2021), Belgian/Flemish novelist Renée Aspe (1922–1969), French painter