5-Methyltetrahydrofolate:corrinoid/iron-sulfur protein Co-methyltransferase

5-methyltetrahydrofolate:corrinoid/iron-sulfur protein Co-methyltransferase (, acsE (gene)) is an enzyme with systematic name 5-methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase. This enzyme catalyses the following chemical reaction

[Methyl-Co(III) corrinoid Fe-S protein] + tetrahydrofolate a [Co(I) corrinoid Fe-S protein] + 5-methyltetrahydrofolate

This enzyme catalyses the transfer of a carbon atom and associated hydrogen atoms from the N5 position of methyltetrahydrofolate to the 5-methoxybenzimidazolylcobamide cofactor of a corrinoid/Fe-S protein, containing a corrin ring similar to that in cobalamin. Although called a methyl transferase, the net transfer is of one carbon atom and two hydrogen atomsthe methyltetrahydrofolate contains only two hydrogen atoms more than the tetrahydrofolate. The cobalt atom is able to change oxidation state by obtaining electrons from the 4Fe-4S complex in the protein.

References

External links