2-Ketoarginine methyltransferase (, mrsA (gene)) is an enzyme with systematic name S-adenosyl-L-methionine:5-carbamimidamido-2-oxopentanoate S-methyltransferase. This enzyme catalyses the following chemical reaction
This is a methylation reaction in which the methyl group comes from the cofactor, S-adenosyl methionine (SAM), which becomes S-adenosyl-L-homocysteine (SAH). The enzyme was characterised from Pseudomonas syringae. It is involved in production of the rare amino acid 3-methylarginine. Other organisms use it to incorporate that amino acid into arginomycin.
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