Clopton is both a surname and a given name. Notable people with the name include:
David Clopton (1820–1892), Alabama politician Hugh Clopton (1496), Lord Mayor of the City of London John Clopton (1756–1816), a United States Representative Walter Clopton (died 1400), English lawyer and Chief Justice of the King's Bench Clopton Havers (1657–1702) pioneering English physician Clopton Lloyd-Jones (1858–1918), English businessman, footballer and cricketer