Cristescu is a Romanian surname. Notable people with it include:
Constantin Cristescu, Romanian General Daniel Cristescu, Romanian football defender Eugen Cristescu, Romanian secret police head Gheorghe Cristescu, Romanian socialist Marian Cristescu, Romanian football midfielder Melania Cristescu, Romanian–Canadian biologist and ecologist Silvian Cristescu, Romanian former professional footballer Vintilǎ Cristescu, Romanian long-distance runner
See also Cristian (disambiguation) Cristești (disambiguation) Cristea (surname)