Jeffords is a surname. Notable people with the surname include:
Carl Jeffords (1888–1972), American politician from Nebraska Elza Jeffords (1826–1885), American politician from Mississippi Harrison Jeffords (1834–1863), American colonel and hero of the American Civil War Jim Jeffords (1934–2014), American former U.S. Senator from Vermont Olin M. Jeffords (1890–1964), American attorney and judge Tom Jeffords (1832–1914), American United States Army scout, Indian agent, prospector, and prominent resident of the Arizona Territory
See also Jefford