Ayre is a surname. Notable people with the surname include:
Sir Amos Ayre (1885–1952), English shipbuilder and high-ranking Admiralty official Bella Ayre (born 1998), Australian rules footballer Billy Ayre (1952–2002), English footballer Bobby Ayre (1932–2018), English former footballer Calvin Ayre (born 1961), Canadian founder of the Bodog online gaming and entertainment brand Charles R. Ayre (1819–1889), Newfoundland merchant and politician Colin Ayre (1956–2023), English former footballer Garry Ayre (born 1953), Canadian former soccer player Jack Ayre (1894–1977), Canadian entertainer James S. Ayre (1881–1953), businessman and political figure in Newfoundland John B. Ayre (1850–1915), merchant and political figure in Newfoundland, son of Charles Ayre Keegan Ayre (born 1988), Canadian soccer player Kristian Ayre (born 1977), Canadian actor Lewis H.M. Ayre (1914–1985), Canadian businessman Richard James Ayre, English journalist Sanjay Ayre (born 1980), Jamaican sprinter William Ayre (1782 or 1783–1855), Canadian educator