Worthen is a surname. Notable people with the surname include:
Amos Henry Worthen, American geologist Amy Namowitz Worthen (born 1946), American artist Augusta Harvey Worthen (1823–1910), American author and teacher Clyde Worthen, American judoka Ezekiel Worthen (1710–1793), American military officer Joey Worthen (born 1979), American soccer player John Worthen (literary critic), English academic, literary critic and biographer John E. Worthen (born 1933), American university president Kevin J Worthen (born 1957), American lawyer and BYU president Molly Worthen (born 1981), American writer Naz Worthen (born 1966), American football player Rande Worthen (born 1956), American politician Sam Worthen (born 1958), American basketball player Sandra Worthen (1937-2022), American politician Shawn Worthen (born 1978), American football player Trebor Worthen (born 1980), American politician William Ezra Worthen (1819–1897), American civil engineer