Clapton is an English surname. Notable people with the surname include:
Danny Clapton (1934–1986), English footballer Eric Clapton (born 1945), English musician Michele Clapton, British costume designer Nathaniel L. Clapton (1903–1967), English schoolmaster Nicholas Clapton (born 1955), English singer and writer Richard Clapton (born 1951), Australian musician
Fictional characters Jamie Clapton, from the British soap opera Doctors