William DuBois may refer to:
William DuBois (architect) (1879–1953), American architect and politician based in Cheyenne, Wyoming William Dubois (usher) (1841–1910), Chief Usher of the White House, 1881–1902 William DuBois (writer) (1903–1997), American playwright, novelist, and editor of The New York Times Book Review William Edward Burghardt Du Bois (1868–1963), American sociologist, historian, and civil rights activist William H. Dubois (1835–1907), Vermont businessman and political figure William Pène du Bois (1916–1993), French-American author and illustrator