(, Cfr, Cfr methyltransferase, Cfr rRNA methyltransferase) is an enzyme with systematic name . This enzyme catalyses the following chemical reaction

2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA 2 S-adenosyl-L-homocysteine + 2,8-dimethyladenine2503 in 23S rRNA

This enzyme contains an [4Fe-S] cluster.

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