Sarcosine/dimethylglycine N-methyltransferase

Sarcosine/dimethylglycine N-methyltransferase (, ApDMT, sarcosine-dimethylglycine methyltransferase, SDMT, sarcosine dimethylglycine N-methyltransferase, S-adenosyl-L-methionine:N,N-dimethylglycine N-methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:sarcosine(or N,N-dimethylglycine) N-methyltransferase (N,N-dimethylglycine(or betaine)-forming). It catalyses the following overll chemical reaction

The enzyme adds two methyl groups, with the intermediate, N.N-dimethylglycine, being methylated again to give the product betaine, trimethylglycine. The methyl groups come from the cofactor, S-adenosyl methionine (SAM), which becomes S-adenosyl-L-homocysteine (SAH). The enzyme was characterised from the cyanobacterium, Aphanothece halophytica. In this organism, glycine is converted to sarcosine by the enzyme glycine/sarcosine N-methyltransferase.

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