Several special routes of U.S. Route 29 (US 29) exist. In order from south to north, they are as follows.

Alabama

Union Springs truck route

U.S. Route 29 Truck (US 29 Truck) is a truck route along Martin Luther King Boulevard South that is signed along State Route 197 in Union Springs, Alabama.

Georgia

LaGrange business loop

U.S. Highway 29 Business (US 29 Bus.) was a business route in LaGrange, Georgia, that ran from the US 27/US 29 overlap along Greenville Street to Hill Road to Hogansville Road, ending on US 29 at Commerce and Youngs Mill roads. The route also ran in conjunction with State Route 14 Connector (SR 14 Conn.). Today, SR 14 Conn. runs only along Broad Street.

Palmetto–Red Oak alternate route

U.S. Highway 29 Alternate (US 29 Alt.) is a alternate route of US 29 that exists entirely within the southern and southeastern parts of Fulton County, Georgia. It connects Palmetto with Red Oak, located southwest of Atlanta. It is concurrent with SR 14 Alt. for its entire length.

Decatur business loop

U.S. Highway 29 Business (US 29 Bus.) was a business route in Decatur, Georgia, that included Ponce de Leon Avenue and Church Street.

Lawrenceville–Winder business loop

U.S. Highway 29 Business (US 29 Bus.) was established in 1998 along a former segment of US 29 from Lawrenceville to Winder, Georgia, and travels concurrent with SR 8. The highway begins just northeast of Lawrenceville and heads north of SR 316 (University Parkway, which is concurrent with the US 29 mainline) from Dacula. Then, it continues parallel to US 29/SR 316 through the cities of Auburn, Carl, and Winder. Then, it travels concurrent with SR 53 and heads southeast to intersect with US 29/SR 316 again, therefore making this the end of US 29 Bus. The portion of US 29 Bus. from the western end of the SR 11 and SR 53 concurrencies in Winder to its eastern terminus is part of the National Highway System, a system of routes determined to be the most important for the nation's economy, mobility, and defense.

Lawrenceville–Athens business loop

U.S. Highway 29 Business (US 29 Bus.) was a short-lived business loop of US 29 in 1950 that spanned from Lawrenceville to Athens, Georgia, and bypassed communities such as Winder and Bogart.

Athens temporary route

South Carolina

Greenville alternate route

US 29 Alternate in Greenville is a brand-new route that was established in 2025.

Anderson alternate route

Anderson business loop

U.S. Highway 29 Business (US 29 Bus.) is a business route of US 29 that partially exists within the city limits of Anderson, South Carolina. It was established in 1947 when US 29 was rerouted onto a bypassing route around Anderson; it follows the original alignment through Anderson, via Sayre Street, Main Street, Greenville Street, and Williamston Road. In 1962, it was rerouted from Main Street to Murray Avenue through downtown. The route is two lanes along both Sayre Street and Williamston Road and four lanes along Murray Avenue and Greenville Street. Signage in area clearly marks the business loop but indicates the mainline or bypass US 29 as a truck route.

Williamston connector route

U.S. Highway 29 Connector (US 29 Conn.) is a connector route that connects US 29 west-southwest of Williamston, South Carolina, with South Carolina Highway 20 (SC 20) in the town. It is unsigned, except for signs at each terminus.

Greenville alternate route

U.S. Highway 29 Alternate (US 29 Alt.) was established in 1938 as renumbering of mainline US 29 through Greenville, South Carolina. The routing took Main Street through the downtown area and then continued north via Buncombe Road, Rutherford Avenue, and Camp Road into Greer. In 1948, it was decommissioned and downgraded to secondary.

Greenville business loop

U.S. Highway 29 Business (US 29 Bus.) was a business route of US 29 in Greenville, South Carolina. It was established in 1958 when mainline US 29 was rerouted onto new freeway south of Greenville. The business loop followed Grove Road, Augusta Street, Main Street, Elford Street, and Wade Hampton Boulevard. In 1962, it was decommissioned when US 29 returned to its original alignment through Greenville.

Greenville connector route

U.S. Highway 29 Connector (US 29 Conn.) is a connector route that connects US 276 (East Stone Avenue) with US 29 (North Church Street/Wade Hampton Boulevard) entirely within the city limits of Greenville, South Carolina. It shares the Wade Hampton Boulevard name with US 29 and is an unsigned highway.

Greenville spur route

U.S. Highway 29 Spur (US 29 Spur) is a spur route that exists entirely within the city limits of Greenville, South Carolina. It connects US 29 (North Church Street) with US 276 (East Stone Avenue). It is known as Column Street and is an unsigned highway.

Greenville–Taylors alternate route 1

Greenville–Taylors alternate route 2

Wade Hampton connector route

U.S. Highway 29 Connector (US 29 Conn.) is a connector route that connects SC 291 (Pleasantburg Drive), on the Greenville–Wade Hampton line, with US 29 (Wade Hampton Boulevard), in Wade Hampton proper. It is entirely concurrent with Pine Knoll Drive and is an unsigned highway.

Wellford alternate route

Spartanburg–Blacksburg alternate route

U.S. Highway 29 Alternate (US 29 Alt.) was established in 1954 as renumbering of mainline US 29 through Spartanburg, Cowpens, Gaffney, and Blacksburg, South Carolina. In 1962, mainline US 29 was moved back on its original routing after sharing a few years with Interstate 85 (I-85), thus decommissioning the alternate route.

Fairforest alternate route

Spartanburg connector route

U.S. Highway 29 Connector (US 29 Conn.) was a connector route on the brief section of John B. White Sr. Boulevard that was previously unsigned in Spartanburg, South Carolina. It connected US 29 with SC 296. The route was removed when SC 296 was extended over it.

North Carolina

Bessemer City alternate route

U.S. Highway 29A (US 29A) was a short-lived alternate route in Bessemer City, North Carolina, that was established in 1937 after mainline US 29/US 74 was rerouted on a more direct path from Kings Mountain to Gastonia. In 1938, it was decommissioned and renumbered as parts of North Carolina Highway 161 (NC 161) and NC 274.

Charlotte business loop

U.S. Highway 29 Business (US 29 Bus.) was established in 1960 in Charlotte, North Carolina, when US 29 was rerouted onto new freeway in concurrency with I-85. The business loop began at the intersection Wilkinson Boulevard and Little Rock Road, in concurrency with US 74; it followed the old mainline route through Charlotte via Morehead, Graham, Dalton, and Tryon streets, reconnecting with mainline US 29 what is known today as the I-85 Connector (exit 42). In 1962, it was extended west into Belmont, at the intersection of Wilkinson Boulevard and Park Street (NC 273). In 1963, the route was decommissioned when mainline US 29 was moved back to its original alignment through Charlotte.

Concord–China Grove alternate route

Kannapolis alternate route 1

U.S. Highway 29A (US 29A) was a short-lived alternate route in Kannapolis, North Carolina, which was established in 1938 after mainline US 29 moved on a more bypass routing through Kannapolis, Landis, and China Grove. In 1940, mainline US 29 swapped with US 29A.

Kannapolis alternate route 2

U.S. Highway 29A (US 29A) was established in 1940 in Kannapolis, North Carolina, as a new alternate routing from what is now the University City area to China Grove. After passing through Concord, it would have a brief reconnection with mainline US 29, before continuing its route through Kannapolis and Landis. In 1948, mainline US 29 was moved back onto the alternate route, thus decommissioning it.

Kannapolis alternate route 3

U.S. Highway 29A (US 29A) was established in 1948 in Kannapolis, North Carolina, as a renumbering of mainline US 29 from what is now the University City area to China Grove, being the third and final alternate route through Kannapolis. In 1953, US 29A was removed south of Concord and rerouted from Church Street to meet back with mainline US 29 along Cabbarrus Avenue (replacing an unconfirmed US 29A-1). The old routing continued as NC 49, except for Old Concord Road; in Concord, Union Street became part of US 601, while Wilshire Avenue and Old Charlotte Road were downgraded. In 1954, US 29A's southern terminus was truncated north of Concord, at US 29/US 601. In July 1997, the entire alternate route was decommissioned.

Salisbury alternate route

U.S. Highway 29A (US 29A) was established around 1945 as a new alternate routing of US 29 in downtown Salisbury, North Carolina. The short alternate loop used Bank, Lee, and Liberty streets. Around 1954, it was decommissioned and replaced by truck routes of US 52 and US 601.

Salisbury business loop

U.S. Highway 29 Business (US 29 Bus.) was established in 1960 in Salisbury, North Carolina, as a renumbering of mainline US 29, which was rerouted east onto a completed section of I-85. The business loop stayed along Main Street in both Salisbury and Spencer, reconnecting north of the Yadkin River. By 1964, the business loop was decommissioned when mainline US 29 reverted to its original alignment.

Lexington alternate route

U.S. Highway 29A (US 29A) was established in 1952 as a renumbering of US 29 through Lexington, North Carolina, via Main Street. In 1960, it was renumbered as US 29 Bus.

Lexington business loop

U.S. Highway 29 Business (US 29 Bus.) was established in 1960 in Lexington, North Carolina, as a renumbering of US 29A, via Main Street; the entire route was in concurrency with US 70 Bus. The route remained unchanged until September 2003 when it was decommissioned.

Thomasville alternate route

U.S. Highway 29A (US 29A) was established in 1952 as a renumbering of US 29/US 70 through downtown Thomasville, North Carolina, via Main Street and Turner Road; the entire route was in concurrency with US 70A. In 1957, it was absorbed by US 29A from High Point.

Thomasville business loop

U.S. Highway 29 Business (US 29 Bus.) was established in 1960 was a renumbering of US 29A through downtown Thomasville, North Carolina, via Main Street and Turner Road; the entire route was in concurrency with US 70 Bus. In 1962, it was decommissioned.

High Point alternate route 1

U.S. Highway 29A (US 29A) in High Point, North Carolina, was established in 1934 as a renumbering of NC 10A; the entire route was in concurrency with US 70A. It went north along Westchester Drive then east on Lexington Road/Greensboro Road back to mainline US 29/US 70. Around 1948, this alignment was replaced by mainline US 29/US 70.

High Point alternate route 2

U.S. Highway 29A (US 29A) in High Point, North Carolina, was established around 1948 after a renumbering of the mainline US 29/US 70 switched to follow the first alternate alignment through the city; the entire route was in concurrency with US 70A. The original routing followed English Road, Main Street, and Montlieu Avenue before reconnecting with the mainlines. In 1957, US 29A was extended on both directions: south replacing mainline US 29/US 70 along English Road into Thomasville to combine with its US 29A, via Main Street and Turner Road, while north replacing mainline US 29 through Jamestown and Greensboro. Its concurrency with US 70A was decommissioned that same year. In 1960, US 29A was truncated north of Thomasville, at US 29/US 70, being replaced by US 29 Bus./US 70 Bus. through Thomasville. In 1969, US 29A was rerouted in Greensboro onto Lee Street (NC 6), Murrow Boulevard, and Summit Avenue; part of its former alignment continued on as US 421. In 1977, US 29A was rerouted in High Point to follow Kivett Drive then north onto College Drive/Harrison Street; its old alignment along Main Street became part of US 311. Around 1991, the entire route was decommissioned, most of it becoming secondary, except for English Road continuing as NC 68.

Greensboro alternate route