James Wadsworth may refer to:
James Wadsworth (Jesuit) (1572–1623), English Catholic priest and Jesuit James Wadsworth (Spanish scholar and pursuivant) (1604–1656?), son of the Jesuit James Wadsworth (lawyer) (1730–1816), American jurist and politician James Wadsworth (of Geneseo) (1768–1844), American pioneer and philanthropist James Wadsworth (mayor) (1819–1891), American politician, mayor of Buffalo, New York James S. Wadsworth (1807–1864), American soldier James W. Wadsworth (1846–1926), American politician - House James W. Wadsworth Jr. (1877–1952), American politician - Senate James Jeremiah Wadsworth (1905–1984), American diplomat