5-hydroxyfuranocoumarin 5-O-methyltransferase (, furanocoumarin 5-methyltransferase, furanocoumarin 5-O-methyltransferase, bergaptol 5-O-methyltransferase, bergaptol O-methyltransferase, bergaptol methyltransferase, S-adenosyl-L-methionine:bergaptol O-methyltransferase, BMT, S-adenosyl-L-methionine:5-hydroxyfuranocoumarin 5.1-O-methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:5-hydroxyfurocoumarin 5-O-methyltransferase. This enzyme catalyses the following chemical reaction
(1) S-adenosyl-L-methionine + a 5-hydroxyfurocoumarin S-adenosyl-L-homocysteine + a 5-methoxyfurocoumarin (general reaction) For example, bergaptol is converted to bergapten:
These are methylation reaction in which the methyl group comes from the cofactor, S-adenosyl methionine (SAM), which becomes S-adenosyl-L-homocysteine (SAH).
The enzyme methylates the 5-hydroxy group of some other hydroxy- and methylcoumarins, giving isopimpinellin and related products.
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