GB3 may refer to:

GB3 Championship, an open wheel motor racing series Globotriaosylceramide - It is also known as CD77, Gb3, and ceramide trihexoside Greater Brisbane League - formerly Greater Brisbane Base Ball Board, an Australian baseball league Ghostbusters: Afterlife (also known as Ghostbusters 3, and internationally as Ghostbusters: Legacy, Ghostbusters: From Beyond, and Ghostbusters: Rise), a sequel to the original Ghostbusters film. GB3, a solo music project by Australian performer Glenn Bennie