Abruzzese () is an Italian surname, meaning literally "Abruzzian" or "from Abruzzo". Notable people with the surname include:
David Abruzzese (born 1969), Welsh footballer Giuseppe Abruzzese (born 1981), Italian footballer Ray Abruzzese (1937–2011), American football player Nick Abruzzese (born 1999), American ice hockey player.
People with a similar surname include: Dave Abbruzzese (born 1968), American drummer Roberto Abrussezze (born 1948), Brazilian football manager and former player.
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