Diapolycopene oxygenase (, crtP) is an enzyme with systematic name 4,4'-diapolycopene,AH2:oxygen oxidoreductase (4,4'-hydroxylating). This enzyme catalyses the following chemical reaction

4,4'-diapolycopene + 4 AH2 + 4 O2 4,4'-diapolycopenedial + 4 A + 6 H2O

Diapolycopene oxygenase is involved in the biosynthesis of C30 carotenoids such as staphyloxanthin.

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