Steroid 15beta-monooxygenase (, cytochrome P-450meg, cytochrome P450meg, steroid 15beta-hydroxylase, CYP106A2, BmCYP106A2) is an enzyme with systematic name progesterone,reduced-ferredoxin:oxygen oxidoreductase (15beta-hydroxylating) . It catalyses the hydroxylation of some steroids, for example the conversion of progesterone to 15β-hydroxyprogesterone:
The enzyme from Bacillus megaterium is an oxidoreductase which uses molecular oxygen to insert a hydroxy group at position 15β of steroids that have 3-oxo group and a double bond at position 4. It requires ferredoxin to transfer electrons to the cytochrome P450 active site.
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