Smalls is a surname. Notable people with the surname include:
Alexander Smalls (born 1952), American restaurateur Bertie Smalls (1935–2008), British supergrass Biggie Smalls, former name of The Notorious B.I.G. Charlie Smalls (1943–1987), composer and songwriter Chris Smalls (born 1988), American labor organizer Cliff Smalls (1918–2008), American jazz trombonist, pianist, conductor and arranger Fred Smalls (born 1963), American football linebacker Joan Smalls (born 1988), Puerto Rican fashion model Marlena Smalls, American educator and musician Robert Smalls (1839–1915), South Carolina politician and former slave Tiger Smalls (born 1969), American boxing trainer Tionna T. Smalls (born 1984), American author and media personality Tommy Smalls (1926–1972), New York radio disc jockey known as "Dr. Jive"
Fictional characters: Derek Smalls, bassist in the parody heavy metal band Spinal Tap Leonard Smalls, Lone Biker of the Apocalypse in Raising Arizona Scotty "You're killin' me" Smalls, fifth-grade protagonist in The Sandlot Detective Smalls, a character from the movie Ruby, played by John Roselius