Pentalenene oxygenase (, formerly , PtlI) is an enzyme with systematic name pentalenene,NADPH:oxygen 13-oxidoreductase. This enzyme is involved in the biosyntheses of pentalenolactone and other antibiotics. Additionally, it catalyses the following overall chemical reactions:
Pentalenene oxygenase from Streptomyces avermitilis is an oxidoreductase which uses molecular oxygen to insert a hydroxy group into 1-deoxypentalenic acid. It requires ferredoxin to transfer electrons to the cytochrome P450 active site.
The starting material is made as part of the biosynthetic pathway to pentalenolactone.
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