Vitamin D3 24-hydroxylase (, CYP24A1) is an enzyme with systematic name calcitriol,NADPH:oxygen oxidoreductase (24-hydroxylating). It catalyses two related chemical reactions:
Calcetriol is the active form of vitamin D3 found in the kidneys. The enzyme can further oxidise calcitetrol, leading finally to calcitroic acid.
Calcifediol also acts as a substrate and is oxidised to the corresponding 24-hydroxy compound, secalciferol.
Vitamin D3 24-hydroxylase is an oxidoreductase that uses molecular oxygen in an oxidation reaction which requires adrenal ferredoxin to transfer electrons from nicotinamide adenine dinucleotide phosphate to its cytochrome P450 active site.
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