Epi-isozizaene 5-monooxygenase (, CYP170A1) is an enzyme with systematic name (+)-epi-isozizaene,NADPH:oxygen oxidoreductase (5-hydroxylating). This enzyme catalyses the following overall chemical reaction:
The enzyme from Streptomyces coelicolor is an oxidoreductase which uses molecular oxygen to insert a hydroxy group into (+)-epi-isozizaene and then further oxidises that intermediate to the ketone product. It requires ferredoxin to transfer electrons to the cytochrome P450 active site.
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