Tranquilino is a masculine given name. Notable people with the name include:

Tranquilino de Bonilla y Herdocia (1797–1864), Costa Rican politician Tranquilino Garcete (1907–?), Paraguayan footballer Tranquilino Luna (1849–1892), American politician Tranquilino Berrios (1918-2007), Puerto Rican procer