A taurochenodeoxycholate 6alpha-hydroxylase (), (also called taurochenodeoxycholate 6alpha-monooxygenase) is an enzyme with systematic name taurochenodeoxycholate,NADPH:oxygen oxidoreductase (6alpha-hydroxylating). In humans, the multifunction protein CYP3A4 carries out this role among many others, while a separate protein in pigs, CYP4A21, has also been found to catalyze this same reaction. This enzyme catalyses some hydroxylation reactions of bile acids.
Reactions catalysed The bile acid, lithocholic acid, is converted to hyodeoxycholic acid:
The enzyme uses a combination of molecular oxygen and nicotinamide adenine dinucleotide phosphate (NADPH) for the oxidation.
Similarly, taurochenodeoxycholic acid is converted to taurohyocholic acid:
The enzyme is a cytochrome P450 protein containing heme.
See also CYP3A4
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