Wettstein is a Swiss surname. Bearers of the name include:
Bryce Wettstein (born 2004), American skateboarder Carla Wettstein (born 1946), Swiss and Australian chess master Diter von Wettstein (1929–2017), plant geneticist Fritz von Wettstein (1895–1945), Austrian botanist Johann Jakob Wettstein (1693–1754), Swiss theologian Johann Rudolf Wettstein (1594–1666), Swiss diplomat Otto von Wettstein (also given as Otto Wettstein-Westersheimb) (1892–1967), Austrian zoologist Richard Wettstein (1863–1931), Austrian botanist
See also Wettstein system, system of plant taxonomy developed by Richard Wettstein