Sulfur dioxygenase (, sulfur oxygenase, sulfur:oxygen oxidoreductase) is an enzyme with systematic name S-sulfanylglutathione:oxygen oxidoreductase. This enzyme catalyses the following chemical reaction

sulfur + O2 + H2O sulfite + 2 H+ (overall reaction) (1a) glutathione + sulfur S-sulfanylglutathione (spontaneous reaction) (1b) S-sulfanylglutathione + O2 + H2O glutathione + sulfite + 2 H+

This enzyme contains iron.

In humans, sulfur dioxygenase is needed to detoxify sulfide.

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