Maccioni is a surname. Notable people with the surname include:
Alejandro Maccioni Seisdedos (1919—2014), Chilean chess player and pediatrician Antonio Machoni or Antonio Maccioni (1671–1753), Italian jesuit, linguist and cartographer Enrico Maccioni (born 1940), Italian painter of contemporary art Giovanni Battista Maccioni (floruit 1651–1674), Italian composer, and librettist Pierre-Henry Maccioni (born 1948), French civil servant Sirio Maccioni (1932-2020), Italian restaurateur and author Sonia Maccioni (born 1966), Italian athletics champions in women’s marathon
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