Buttle is a surname. Notable people with the surname include:
Cecil Buttle (1906–1988), English cricketer Frank Buttle (1878–1953), English social worker, founder of Buttle UK Gladwin Albert Hurst Buttle (1899–1983), British pharmacologist (brother of Frank) Greg Buttle (born 1954), retired American football linebacker Jeffrey Buttle (born 1982), Canadian figure skater Keith Buttle (1900–1973), New Zealand businessman and politician Robert D. Buttle (died 1901), the sole Brooklyn survivor of the Marine battalion which took part in the Mexican–American War Steve Buttle (1953–2012), English footballer and manager
Fictional characters: Buttle family, characters from the 1985 film Brazil