Santisteban is a Spanish-language surname. Notable people with the surname include:
Anna Santisteban (1914–2003), Puerto Rican businesswoman Juan Santisteban (born 1936), Spanish footballer and manager Fernando Silva Santisteban (1929–2006), Peruvian historian, anthropologist, and academic
See also Santisteban del Puerto, city in the province of Jaén, Spain