Mnatsakanyan or Mnatsakanian or Mnatsaganian (, ) is an Armenian surname. Notable people with the surname include:
Aik Mnatsakanian (born 1995), Georgian-born Bulgarian sport wrestler Albert Mnatsakanyan (born 1999), Armenian and Russian football player Alina Mnatsakanian (born 1958), Iranian-born American-Swiss visual artist Eduard Mnatsakanian (1938–2016), Armenian chess player Garnik Mnatsakanyan (born 1989), Armenian freestyle wrestler Karen Mnatsakanyan (born 1977), Armenian sport wrestler Lala Mnatsakanyan (1957–2024), Armenian actress Levon Mnatsakanyan (born 1965), Minister of Defence of Artsakh Mamikon Mnatsakanian (1942–2021), Armenian mathematician Mkhitar Mnatsakanyan (born 1950), Armenian politician Norayr Mnatsakanyan (1923–1986), Armenian singer Stepan Mnatsakanian, Soviet Armenian architect Zohrab Mnatsakanian (born 1966), Armenian diplomat