(−)-Isopiperitenone reductase () is an enzyme with systematic name (+)-cis-isopulegone:NADP+ oxidoreductase that is found in peppermint. It catalyses the following chemical reaction:
The three substrates of this enzyme are (-)-isopiperitenone, reduced nicotinamide adenine dinucleotide phosphate (NADPH), and a proton. It converts them to (+)-cis-isopulegone and oxidised NADP+.
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