(S)-sulfolactate dehydrogenase (, (2S)-3-sulfolactate dehydrogenase, SlcC) is an enzyme with systematic name (2S)-sulfolactate:NAD+ oxidoreductase. This enzyme catalyses the following chemical reaction:

This bacterial (Chromohalobacter salexigens) enzyme acts on the 3-sulfolactate.

See also (2R)-3-sulfolactate dehydrogenase (NADP+) which catalyses the same reaction using the enantiomer of the starting material

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