The Guye () is a long river in the Saône-et-Loire département, central eastern France. It flows primarily south, before turning east-northeast near Salornay-sur-Guye and flowing into the Grosne. It is a left tributary of the Grosne into which it flows between Malay and Savigny-sur-Grosne.

Communes along its course The following communes, ordered from source to mouth, lie along the Guye: Sainte-Hélène Moroges Bissey-sous-Cruchaud Sassangy Cersot Savianges Germagny Saint-Martin-du-Tartre Genouilly Joncy Burzy Saint-Martin-la-Patrouille Saint-Huruge Sailly Sigy-le-Châtel Salornay-sur-Guye Cortevaix Bonnay Malay Savigny-sur-Grosne

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