Caskey is a surname. Notable people with the surname include:
Alex Caskey (born 1988), American soccer player Billy Caskey (born 1954), Northern Ireland footballer C. Thomas Caskey, American physician and geneticist Craig Caskey (born 1949), American baseball player Darren Caskey (born 1974), English footballer Elizabeth Caskey (1910–1994), Classical scholar John Caskey (1908–1981), American archaeologist and classical scholar Lafayette Caskey (1824–1881), American politician and carpenter Caskey (rapper), American rapper