Piccolomini is the name of an Italian noble family, prominent in Siena from the beginning of the 13th century.
Piccolomini may also refer to:
People Alessandro Piccolomini (1508–1579), Italian humanist and philosopher Ascanio I Piccolomini (died 1597), archbishop of Siena 1588-1597 Ascanio II Piccolomini (1590–1671), archbishop of Siena 1629-1671 Costanza d'Avalos Piccolomini (died 1560), duchess of Amalfi Enea Silvio Piccolomini (general) (ca.1640–1689), Italian nobleman Enea Silvio Bartolomeo Piccolomini, better known as Pope Pius II Francesco Piccolomini (Jesuit), Italian Jesuit Francesco Todeschini Piccolomini (1439-1503), better known as Pope Pius III Giovanni Piccolomini (1475–1537), Italian papal legate and Cardinal Jacopo Piccolomini-Ammannati (1422-1479), also known as Giacomo Piccolomini, Italian Renaissance cardinal and humanist Joachim Piccolomini (1258-1305), also known as Joachim of Siena or Giovacchino Piccolomini, Italian Servite tertiary from Siena María Carla Piccolomini (born 1980), Argentine politician Marietta Piccolomini (1834-1899), Italian soprano Ottavio Piccolomini (1599–1656), Italian Fieldmarshal
Other Palazzo Piccolomini, Pienza, Italy Piccolomini (crater), a prominent lunar impact crater Piccolomini Altarpiece, an altarpiece in Siena Cathedral, Siena, Italy Piccolomini Library, in the Cathedral of Siena, Italy Mass in C major, K. 258 by Wolfgang Amadeus Mozart, sometimes known as the Piccolomini Mass