George Clayton may refer to:
George Clayton (writer), a writer who wrote a book about angels George W. Clayton, a businessman and philanthropist in Denver, Colorado George Clayton Johnson, an American science fiction writer Christopher Clayton (businessman) (George Christopher Clayton, 1869–1945), British scientist, industrialist and politician George Clayton (courtier), see Michael Bowes-Lyon, 18th Earl of Strathmore and Kinghorne George Clayton (minister), see Alfred Sturge