Santa Maria Island is the southernmost of the Azores, a Portuguese archipelago in the North Atlantic Ocean.

Santa Maria Island may also refer to:

Santa María Island, Chile, in the Bío Bío Region of Chile Santa Maria Island, a former name of Gaua, Vanuatu Santa Maria Island, a former name of Floreana Island in the Galápagos Archipelago, Ecuador

See also Santa Maria (disambiguation)